Tydol 10 » 0 An opioid painkiller called a tablet is used to treat moderate to severe Acute Pain. An unpleasant sensory and expressive experience brought on by a potential or actual tissue injury is pain. The active ingredient in Tydol 100 Tablets is Tapentadol, which acts directly on opioid receptors in the central nervous system to block the transmission of pain signals from the brain to the body.